PTU-066 New Insight into the Mucosal Profile of Eicosanoid Mediators in Ulcerative Colitis

Measurement of in vivo rectal mucosal cytokine and eicosanoid production in ulcerative colitis using filter paper.

BACKGROUND Excessive mucosal generation of cytokines and eicosanoids has been reported in vitro in ulcerative colitis (UC) using traumatising biopsy techniques, and in vivo using time consuming rectal dialysis. AIMS To validate a simple filter paper technique to profile rectal mucosal production of cytokines and eicosanoids in vivo in patients with UC compared with controls. PATIENTS Forty ...

Altered Colonic Mucosal Polyunsaturated Fatty Acid (PUFA) Derived Lipid Mediators in Ulcerative Colitis: New Insight into Relationship with Disease Activity and Pathophysiology

OBJECTIVES Ulcerative colitis (UC) is a relapsing inflammatory disorder of unconfirmed aetiology, variable severity and clinical course, characterised by progressive histological inflammation and with elevation of eicosanoids which have a known pathophysiological role in inflammation. Therapeutic interventions targetting eicosanoids (5-aminosalicylates (ASA)) are effective first line and adjunc...

Mucosal bacteria in ulcerative colitis.

Ulcerative colitis (UC) is an acute and chronic inflammatory bowel disease of unknown aetiology, although bacterial species belonging to the normal colonic microbiota are known to be involved in its initiation and maintenance. Several organisms have been linked to the disease; however, mucosa-associated bacteria are more likely to be involved than their luminal counterparts, due to their close ...

Mitophagy: New Insight into the Cardiovascular Aging  

Persistence of mucosal abnormality in ulcerative colitis.

The mechanism by which mucosal change is produced in ulcerative colitis is obscure. Once an attack of the disease has occurred, there is a tendency for the condition to persist or to relapse, and perhaps correlated with this is the fact that the mucosa may remain abnormal in the absence of active clinical disease. Truelove and Richards (1956) pointed out that more than 50% of patients in clinic...